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0 · pfeiffer and ezh2
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2 · ezh2 overexpression
3 · ezh2 overexposure
4 · ezh2 mutant lymphoma
5 · ezh2 inhibition lymphoma
6 · ezh2 inhibition
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GSK126 effectively inhibits the proliferation of EZH2 mutant DLBCL cell lines and markedly inhibits the growth of EZH2 mutant DLBCL xenografts in mice. Together, these data .
Abstract. In eukaryotes, post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the .
Kong D, Heath E, Chen W, Cher ML, Powell I, Heilbrun L, Li Y, Ali S, Sethi S, Hassan O, et al. (2012) Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the .Increasing evidence indicates that enhancer of zeste homolog 2 (EZH2), the catalytic subunit of Polycomb repressor complex 2, is highly expressed in cancer stem cells of numerous . Rao, Z. Y. et al. EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-beta1 and is a predictor of outcome in ovarian carcinoma patients.
EZH2 in MDSCs functions in a unique manner. Lu et al. reported that EZH2 might be an essential element in lncRNA Snhg6-promoted monocytic MDSC differentiation. The . These data suggested that EZH2 contributed to the progression of lung adenocarcinoma, and the suppression of EZH2 inhibited cell growth and sensitized cells to . EZH2-mediated methylation is a potential independent mechanism for epigenetic silencing of tumor suppressor genes in cancer. Recent studies have found that EZH2 is . The enhancer of zeste homolog 2 (EZH2) is encoded by the Enhancer of zeste 2 polycomb repressive complex 2 subunit gene. EZH2 is involved in the cell cycle, DNA damage repair, cell differentiation, autophagy, apoptosis, and immunological modulation.
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Highlights. •. EZH2 catalyzes trimethylation of histone H3 on Lys 27 involved in gene silencing. •. EZH2 plays a crucial role in the development of therapeutic resistance in human . GSK126 effectively inhibits the proliferation of EZH2 mutant DLBCL cell lines and markedly inhibits the growth of EZH2 mutant DLBCL xenografts in mice. Together, these data demonstrate that pharmacological inhibition of EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma. Abstract. In eukaryotes, post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the polycomb.
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Kong D, Heath E, Chen W, Cher ML, Powell I, Heilbrun L, Li Y, Ali S, Sethi S, Hassan O, et al. (2012) Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM. PLoS One, 7:e33729. Google ScholarIncreasing evidence indicates that enhancer of zeste homolog 2 (EZH2), the catalytic subunit of Polycomb repressor complex 2, is highly expressed in cancer stem cells of numerous malignant tumors and has a critical function in cancer stem cell expansion and maintenance.
EZH2 in MDSCs functions in a unique manner. Lu et al. reported that EZH2 might be an essential element in lncRNA Snhg6-promoted monocytic MDSC differentiation. The lncRNA Snhg6 reduces the stability of EZH2 via protein ubiquitination degradation. Rao, Z. Y. et al. EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-beta1 and is a predictor of outcome in ovarian carcinoma patients.
EZH2-mediated methylation is a potential independent mechanism for epigenetic silencing of tumor suppressor genes in cancer. Recent studies have found that EZH2 is overexpressed in a wide range. The enhancer of zeste homolog 2 (EZH2) is encoded by the Enhancer of zeste 2 polycomb repressive complex 2 subunit gene. EZH2 is involved in the cell cycle, DNA damage repair, cell differentiation, autophagy, apoptosis, and immunological modulation.In breast cancer tissue samples, cytoplasmic EZH2 phosphorylated at Thr 367 (pT327 EZH2) was associated with low H3K27me3 levels and a triple negative phenotype. The pT367 EZH2 protein binds to cytoplasmic regulators of cell migration and invasion, and promotes metastasis (66).
Enhancer of zeste homolog 2 (EZH2) is a histone lysine methyltransferase that catalyzes the transfer of a methyl group from the cofactor S -adenosyl methionine (SAM) to H3K27 and functions as part of the PRC2 complex [2]. PRC2 is further thought to facilitate the recruitment of PRC1 to methylated histones to repress the target gene expression [1]. GSK126 effectively inhibits the proliferation of EZH2 mutant DLBCL cell lines and markedly inhibits the growth of EZH2 mutant DLBCL xenografts in mice. Together, these data demonstrate that pharmacological inhibition of EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma. Abstract. In eukaryotes, post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the polycomb.
Kong D, Heath E, Chen W, Cher ML, Powell I, Heilbrun L, Li Y, Ali S, Sethi S, Hassan O, et al. (2012) Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM. PLoS One, 7:e33729. Google ScholarIncreasing evidence indicates that enhancer of zeste homolog 2 (EZH2), the catalytic subunit of Polycomb repressor complex 2, is highly expressed in cancer stem cells of numerous malignant tumors and has a critical function in cancer stem cell expansion and maintenance. EZH2 in MDSCs functions in a unique manner. Lu et al. reported that EZH2 might be an essential element in lncRNA Snhg6-promoted monocytic MDSC differentiation. The lncRNA Snhg6 reduces the stability of EZH2 via protein ubiquitination degradation.
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Rao, Z. Y. et al. EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-beta1 and is a predictor of outcome in ovarian carcinoma patients.
EZH2-mediated methylation is a potential independent mechanism for epigenetic silencing of tumor suppressor genes in cancer. Recent studies have found that EZH2 is overexpressed in a wide range. The enhancer of zeste homolog 2 (EZH2) is encoded by the Enhancer of zeste 2 polycomb repressive complex 2 subunit gene. EZH2 is involved in the cell cycle, DNA damage repair, cell differentiation, autophagy, apoptosis, and immunological modulation.In breast cancer tissue samples, cytoplasmic EZH2 phosphorylated at Thr 367 (pT327 EZH2) was associated with low H3K27me3 levels and a triple negative phenotype. The pT367 EZH2 protein binds to cytoplasmic regulators of cell migration and invasion, and promotes metastasis (66).
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